HitPredict

Interactor 1: SRPRB (Q9Y5M8)
Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)
Gene: SRPRB

Interactor 2: SAR1B (Q9Y6B6)
Small COPII coat GTPase SAR1B (EC 3.6.5.2) (GTP-binding protein B) (GTBPB) (Secretion-associated Ras-related GTPase 1B)
Gene: SAR1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005525 - GTP binding GO:0005789 - endoplasmic reticulum membrane GO:0006886 - intracellular protein transport
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 271 Hs			1 198
+	Sc
		503044 ARF1_YEAST (46-239): 6.75e-76: 230: 21.65		ARF2_YEAST (10-197): 8.45e-77: 229: 26.60
+	Hs
		574648 ARF5_HUMAN (46-240): 5.42e-75: 227: 21.03		ARF4_HUMAN (10-197): 2.61e-74: 223: 27.66
+	Hs
		912847 ARF5_HUMAN (46-240): 5.42e-75: 227: 21.03		ARF6_HUMAN (21-196): 3.66e-74: 222: 30.11
+	Hs
		950750 SRPRB_HUMAN (1-271): 4.47e-69: 216: 100.00		ARF5_HUMAN (10-197): 5.28e-75: 225: 27.66
+	Hs
		574643 ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00		ARF4_HUMAN (10-197): 2.61e-74: 223: 27.66
+	Hs
		913211 SRPRB_HUMAN (1-271): 4.47e-69: 216: 100.00		ARF6_HUMAN (21-196): 3.66e-74: 222: 30.11
+	Hs
		897350 ARF5_HUMAN (46-240): 5.42e-75: 227: 21.03		ARF3_HUMAN (8-197): 1.62e-62: 193: 27.90
+	Sc
		503036 ARF1_YEAST (46-239): 6.75e-76: 230: 21.65		ARF1_YEAST (10-197): 2.45e-59: 185: 27.66
+	Dm
		778363 ARF4_DROME (46-240): 7.12e-75: 227: 22.05		ARF1_DROME (1-197): 2.88e-59: 185: 26.90
+	Hs
		950474 ARF5_HUMAN (46-240): 5.42e-75: 227: 21.03		ARF1_HUMAN (1-197): 1.8e-59: 185: 26.90
+	Hs
		912837 ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00		RAB1A_HUMAN (18-197): 7.2e-62: 192: 19.46
+	Hs
		913100 ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00		RAB1B_HUMAN (18-197): 5.27e-62: 192: 19.46
+	Hs
		912846 ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00		ARF1_HUMAN (1-197): 1.8e-59: 185: 26.90
+	Zm
		73944 B4FAE1_MAIZE (57-268): 6.81e-65: 203: 12.84		B4FAE1_MAIZE (18-197): 1.6e-63: 196: 18.92
+	Zm
		21601 A0A1D6HW42_MAIZE (46-240): 4.09e-65: 203: 22.56		A0A1D6HW42_MAIZE (1-197): 6.36e-62: 192: 25.89
+	Hs
		918846 RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49		RAB1A_HUMAN (18-197): 7.2e-62: 192: 19.46
+	Hs
		918944 RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49		RAB1B_HUMAN (18-197): 5.27e-62: 192: 19.46
+	Mm
		919000 RAB1A_MOUSE (54-265): 1.14e-63: 200: 14.49		RAB1B_MOUSE (18-197): 1.04e-61: 192: 19.46