HitPredict

Interactor 1: DRB1 (O04492)
Double-stranded RNA-binding protein 1 (Protein HYPONASTIC LEAVES 1) (dsRNA-binding protein 1) (AtDRB1)
Gene: DRB1

Interactor 2: DCL2 (Q3EBC8)
Endoribonuclease Dicer homolog 2 (EC 3.1.26.-) (Dicer-like protein 2) (AtDCL2)
Gene: At3g03300

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15821876
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Helicase_C~dsrm, Ribonuclease_3~dsrm
Common GO terms	GO:0004525 - ribonuclease III activity GO:0005634 - nucleus GO:0010267 - ta-siRNA processing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 419 At			1 1388
+	At
		138416 DRB1_ARATH (1-419): 1.99e-169: 482: 100.00		DCL1_ARATH (5-1372): 0: 936: 29.33
+	At
		138410 DRB1_ARATH (1-419): 1.99e-169: 482: 100.00		DCL3_ARATH (26-1384): 0: 801: 27.30
+	At
		952787 DRB4_ARATH (14-262): 2.63e-53: 183: 28.11		DCL4_ARATH (10-1383): 0: 903: 31.76
+	Dm
		55497 Q9VLW8_DROME (13-293): 3.32e-56: 189: 17.18		DCR2_DROME (639-1384): 1.16e-98: 351: 18.86
+	Hs
		322980 STAU1_HUMAN (13-225): 7.67e-47: 171: 17.72		DHX58_HUMAN (23-526): 3.99e-100: 337: 21.71
+	Hs
		585524 E2AK2_HUMAN (7-218): 1.31e-43: 162: 19.73		DHX58_HUMAN (23-526): 3.99e-100: 337: 21.71
+	Hs
		877372 DSRAD_HUMAN (2-213): 6.07e-43: 163: 16.94		RNC_HUMAN (993-1381): 5.4e-88: 316: 19.05
+	Hs
		322538 STAU1_HUMAN (13-225): 7.67e-47: 171: 17.72		CHD3_HUMAN (10-774): 2.77e-79: 291: 13.35
+	Hs
		322641 STAU1_HUMAN (13-225): 7.67e-47: 171: 17.72		CHD4_HUMAN (23-774): 1.36e-78: 289: 12.67
+	Hs
		877324 DSRAD_HUMAN (2-213): 6.07e-43: 163: 16.94		CHD5_HUMAN (23-774): 3.1e-81: 297: 13.33
+	Hs
		877254 DSRAD_HUMAN (2-213): 6.07e-43: 163: 16.94		CHD3_HUMAN (10-774): 2.77e-79: 291: 13.35
+	Hs
		877275 DSRAD_HUMAN (2-213): 6.07e-43: 163: 16.94		CHD4_HUMAN (23-774): 1.36e-78: 289: 12.67
+	Hs
		269869 PRKRA_HUMAN (3-201): 6.06e-54: 183: 18.27		IFIH1_HUMAN (2-571): 4.69e-68: 252: 20.29
+	Hs
		269593 PRKRA_HUMAN (3-201): 6.06e-54: 183: 18.27		RIGI_HUMAN (9-571): 4.27e-68: 250: 21.51
+	Hs
		321872 E2AK2_HUMAN (7-218): 1.31e-43: 162: 19.73		RIGI_HUMAN (9-571): 4.27e-68: 250: 21.51
+	Hs
		322951 STAU1_HUMAN (13-225): 7.67e-47: 171: 17.72		DDX17_HUMAN (3-295): 3.59e-44: 174: 12.00
+	Hs
		322157 STAU1_HUMAN (13-225): 7.67e-47: 171: 17.72		DDX5_HUMAN (1-306): 2.15e-44: 173: 11.50
+	Hs
		269939 PRKRA_HUMAN (3-201): 6.06e-54: 183: 18.27		DICER_HUMAN (1035-1237): 3.22e-16: 86.9: 20.29
+	Hs
		323319 STAU1_HUMAN (13-225): 7.67e-47: 171: 17.72		DICER_HUMAN (1035-1237): 3.22e-16: 86.9: 20.29
+	Hs
		877391 DSRAD_HUMAN (2-213): 6.07e-43: 163: 16.94		DICER_HUMAN (1035-1237): 3.22e-16: 86.9: 20.29