HitPredict

Interactor 1: SC22B (O08547)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) (mSec22b)
Gene: Sec22b

Interactor 2: STX1A (O35526)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.690

Property	Details
Experiments	24705552
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0008021 - synaptic vesicle GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Mm			1 288
+	Hs
		263248 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX1A_HUMAN (1-287): 5.88e-82: 250: 98.61
+	Hs
		263179 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX2_HUMAN (1-288): 5.02e-80: 245: 65.28
+	Hs
		263226 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX4_HUMAN (1-287): 2.08e-63: 203: 43.92
+	Dm
		115805 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		STX1A_DROME (2-287): 5.63e-74: 229: 68.75
+	Rn
		996534 SC22B_RAT (1-215): 6.45e-91: 267: 100.00		STX5_RAT (2-267): 6.05e-49: 167: 19.16
+	Hs
		263279 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX12_HUMAN (27-271): 1.36e-48: 164: 24.60
+	Hs
		178331 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		STX7_HUMAN (45-286): 6.66e-46: 157: 25.71
+	At
		812702 VA722_ARATH (31-199): 6.71e-74: 224: 23.39		SY121_ARATH (10-266): 9.88e-57: 187: 21.51
+	At
		1378372 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY121_ARATH (10-266): 9.88e-57: 187: 21.51
+	Dm
		115812 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		STX4_DROME (28-267): 1.83e-51: 173: 24.58
+	Dm
		115804 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		STX5_DROME (2-268): 2.7e-49: 171: 16.95
+	At
		1352937 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY122_ARATH (25-266): 1.16e-52: 176: 23.60
+	At
		1258650 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY132_ARATH (13-266): 9.86e-52: 173: 23.49
+	At
		812689 VA722_ARATH (31-199): 6.71e-74: 224: 23.39		SY111_ARATH (2-266): 9.08e-50: 168: 23.25
+	At
		1114744 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SY111_ARATH (2-266): 9.08e-50: 168: 23.25
+	At
		249598 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP41_ARATH (31-283): 4.92e-49: 167: 21.62
+	At
		1352876 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP43_ARATH (10-283): 3.16e-48: 165: 20.00
+	At
		1352985 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		SYP42_ARATH (31-283): 3.35e-47: 162: 21.24
+	Sc
		605845 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		SSO2_YEAST (13-278): 1.21e-49: 167: 28.63
+	Sc
		605830 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		SSO1_YEAST (16-268): 1.07e-46: 159: 27.73