HitPredict

Interactor 1: ERR1 (O08580)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: Esrra

Interactor 2: PRGC1 (O70343)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha)
Gene: Ppargc1a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19690166
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription GO:0043565 - sequence-specific DNA binding GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 422 Mm			1 797
+	Mm
		250734 ERR3_MOUSE (25-421): 1.82e-119: 357: 59.45		PRGC1_MOUSE (1-797): 0: 1176: 100.00
+	Hs
		510041 ERR1_HUMAN (1-422): 2.96e-129: 381: 98.11		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Mm
		250740 ERR2_MOUSE (2-421): 3.47e-114: 342: 55.61		PRGC1_MOUSE (1-797): 0: 1176: 100.00
+	Hs
		587203 RXRA_HUMAN (1-419): 1.27e-122: 365: 29.51		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Hs
		914678 ERR3_HUMAN (25-421): 1.82e-119: 357: 59.45		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Mm
		250733 HNF4A_MOUSE (54-417): 8.27e-107: 325: 27.40		PRGC1_MOUSE (1-797): 0: 1176: 100.00
+	Hs
		795608 NR4A2_HUMAN (18-417): 5.96e-115: 350: 27.47		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Mm
		250749 NR1H3_MOUSE (2-416): 5.01e-106: 322: 23.41		PRGC1_MOUSE (1-797): 0: 1176: 100.00
+	Hs
		370621 ESR1_HUMAN (4-419): 4.23e-113: 345: 33.48		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Hs
		500377 RARB_HUMAN (5-418): 7.11e-113: 340: 25.54		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Hs
		782680 HNF4A_HUMAN (54-417): 6.04e-108: 328: 27.95		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Hs
		1269828 ESR2_HUMAN (4-419): 2.65e-100: 310: 32.94		PRGC1_HUMAN (1-797): 0: 1150: 94.49
+	Mm
		139251 ERR1_MOUSE (1-422): 7.26e-136: 397: 100.00		PRGC2_MOUSE (646-795): 6.04e-57: 213: 42.86
+	Hs
		510026 ERR1_HUMAN (1-422): 2.96e-129: 381: 98.11		PRGC2_HUMAN (22-219): 2.49e-60: 223: 35.96
+	Hs
		914660 ERR3_HUMAN (25-421): 1.82e-119: 357: 59.45		PRGC2_HUMAN (22-219): 2.49e-60: 223: 35.96
+	Hs
		369945 ESR1_HUMAN (4-419): 4.23e-113: 345: 33.48		PRGC2_HUMAN (22-219): 2.49e-60: 223: 35.96
+	Hs
		782588 HNF4A_HUMAN (54-417): 6.04e-108: 328: 27.95		PRGC2_HUMAN (22-219): 2.49e-60: 223: 35.96
+	Hs
		874389 NR1H2_HUMAN (1-416): 1.22e-107: 327: 23.26		PRGC2_HUMAN (22-219): 2.49e-60: 223: 35.96
+	Mm
		1257603 NR1H3_MOUSE (2-416): 5.01e-106: 322: 23.41		PRGC2_MOUSE (646-795): 6.04e-57: 213: 42.86
+	Hs
		1138792 ESR2_HUMAN (4-419): 2.65e-100: 310: 32.94		PPRC1_HUMAN (662-797): 1.16e-56: 213: 61.03