Interactor 1: PTEN (O08586)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Interactor 2: PTEN (O08586)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 36417873, 24766807
Identification Methods proximity labelling technology, comigration in non denaturing gel electrophoresis
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PTEN_C2~PTEN_C2, PTEN_C2~Y_phosphatase, Y_phosphatase~Y_phosphatase
Common GO terms GO:0001525 - angiogenesis
GO:0001933 - negative regulation of protein phosphorylation
GO:0002902 - regulation of B cell apoptotic process
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
and 118 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 403
Mm

1 403
+ Hs
+ Hs
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+ Hs
+ Hs
+ Hs
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+ Ca
+ Sp
+ Sc
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024