HitPredict

Interactor 1: DDRGK (Q96HY6)
DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1)
Gene: DDRGK1

Interactor 2: CK5P3 (Q96JB5)
CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)
Gene: CDK5RAP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 32807901, 33961781, 17353931, 20228063, 37595036, unassigned3799
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CDK5RAP3~DDRGK
Common GO terms	GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0032790 - ribosome disassembly GO:0034976 - response to endoplasmic reticulum stress and 5 others more... GO:0044389 - ubiquitin-like protein ligase binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071569 - protein ufmylation GO:0072344 - rescue of stalled ribosome GO:0140501 - positive regulation of reticulophagy
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	314
Hs

1	506

Service provided by Combinatics, Japan

Last updated: 11Aug2025