HitPredict

Interactor 1: SQSTM (O08623)
Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Interactor 2: NTRK1 (P35739)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Slow nerve growth factor receptor) (p140-TrkA) (Trk-A)
Gene: NTRK1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25708205, 18174161, 16246731
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005737 - cytoplasm GO:0005770 - late endosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 439 Rn			1 799
+	Mm
		1112477 SQSTM_MOUSE (1-439): 0: 772: 96.83		NTRK1_MOUSE (1-799): 0: 662: 96.25
+	Hs
		384793 SQSTM_HUMAN (1-439): 0: 713: 88.46		NTRK1_HUMAN (1-799): 0: 640: 85.73
+	Mm
		546304 SQSTM_MOUSE (1-439): 0: 772: 96.83		NTRK2_MOUSE (10-799): 0: 542: 46.86
+	Hs
		1036607 SQSTM_HUMAN (1-439): 0: 713: 88.46		NTRK3_HUMAN (12-799): 0: 550: 47.36
+	Hs
		1036611 SQSTM_HUMAN (1-439): 0: 713: 88.46		NTRK2_HUMAN (10-799): 0: 542: 46.87
+	Hs
		609276 SQSTM_HUMAN (1-439): 0: 713: 88.46		FGFR3_HUMAN (128-799): 6.93e-170: 512: 23.89
+	Hs
		411378 SQSTM_HUMAN (1-439): 0: 713: 88.46		INSR_HUMAN (496-780): 1.53e-67: 246: 41.95