HitPredict - High confidence protein-protein interactions

Interactor 1: BAK (O08734)
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
Gene: Bak1

Interactor 2: BCL2 (P10417)
Apoptosis regulator Bcl-2
Gene: BCL2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12881569
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bcl-2~Bcl-2, BH4~Bcl-2
Common GO terms	GO:0001776 - leukocyte homeostasis GO:0001782 - B cell homeostasis GO:0001783 - B cell apoptotic process GO:0001836 - release of cytochrome c from mitochondria GO:0005739 - mitochondrion and 22 others more... GO:0005741 - mitochondrial outer membrane GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0009410 - response to xenobiotic stimulus GO:0010332 - response to gamma radiation GO:0031966 - mitochondrial membrane GO:0042542 - response to hydrogen peroxide GO:0042803 - protein homodimerization activity GO:0044877 - protein-containing complex binding GO:0045471 - response to ethanol GO:0046902 - regulation of mitochondrial membrane permeability GO:0046930 - pore complex GO:0046982 - protein heterodimerization activity GO:0051400 - BH domain binding GO:0051649 - establishment of localization in cell GO:0051726 - regulation of cell cycle GO:0051881 - regulation of mitochondrial membrane potential GO:0060402 - calcium ion transport into cytosol GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	209
Mm

1	236

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024