HitPredict

Interactor 1: PRDX4 (O08807)
Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4)
Gene: PRDX4

Interactor 2: THIOM (P97493)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: Txn2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31018154
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005739 - mitochondrion GO:0006979 - response to oxidative stress GO:0045454 - cell redox homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 274 Mm			1 166
+	Rn
		751965 PRDX4_RAT (1-274): 3.64e-138: 391: 97.08		PDIA4_RAT (16-165): 5.3e-28: 110: 23.23
+	Mm
		589514 PRDX3_MOUSE (46-274): 7.55e-108: 314: 56.33		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		956730 PRDX2_MOUSE (77-274): 1.52e-105: 306: 67.17		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		727682 PRDX1_MOUSE (77-272): 1.37e-101: 296: 66.50		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Hs
		423216 PRDX4_HUMAN (37-274): 4.97e-116: 335: 94.96		PDIA1_HUMAN (52-166): 3.4e-34: 127: 27.50
+	Hs
		1026686 PRDX4_HUMAN (37-274): 4.97e-116: 335: 94.96		PDIA6_HUMAN (62-165): 2.6e-32: 121: 23.81
+	Hs
		671804 PRDX4_HUMAN (37-274): 4.97e-116: 335: 94.96		PDIA3_HUMAN (49-163): 5.5e-30: 115: 23.53
+	Hs
		531815 PRDX4_HUMAN (37-274): 4.97e-116: 335: 94.96		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Hs
		495475 PRDX2_HUMAN (77-274): 3.69e-105: 305: 67.68		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	Hs
		531737 PRDX3_HUMAN (46-274): 8.45e-107: 311: 57.64		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Hs
		495510 PRDX1_HUMAN (77-272): 5.51e-102: 297: 68.02		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	So
		188731 BAS1_SPIOL (72-273): 3.49e-94: 280: 52.71		TRXM_SPIOL (14-165): 2.43e-39: 133: 23.03
+	At
		1227668 BAS1B_ARATH (65-273): 2.01e-96: 286: 51.66		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	Os
		1150818 BAS1_ORYSJ (72-273): 3.4e-94: 280: 51.47		TRXX_ORYSJ (1-165): 1.48e-35: 123: 22.99
+	At
		1227667 BAS1A_ARATH (72-273): 9.62e-94: 278: 51.96		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	Ss
		852832 Y755_SYNY3 (82-273): 3.06e-91: 270: 54.40		THIO_SYNY3 (59-165): 8.35e-39: 129: 31.78
+	Sc
		611720 TSA1_YEAST (82-274): 3.3e-90: 267: 55.96		TRX2_YEAST (61-154): 7.37e-36: 122: 31.92
+	Sc
		606199 TSA1_YEAST (82-274): 3.3e-90: 267: 55.96		TRX1_YEAST (61-154): 2.56e-35: 120: 37.23
+	Ss
		852848 Y755_SYNY3 (82-273): 3.06e-91: 270: 54.40		THIO1_SYNY3 (65-151): 3.22e-34: 117: 31.03
+	Sc
		606220 TSA2_YEAST (82-274): 2.37e-86: 257: 52.85		TRX1_YEAST (61-154): 2.56e-35: 120: 37.23