HitPredict

Interactor 1: RASM (O08989)
Ras-related protein M-Ras (EC 3.6.5.2) (Muscle and microspikes Ras) (Ras-related protein R-Ras3) (X-Ras)
Gene: Mras

Interactor 2: PK3CA (P42337)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: Pik3ca

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23706742
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 208 Mm			1 1068
+	Mm
		787346 RRAS2_MOUSE (14-194): 5.37e-63: 196: 59.46		PK3CA_MOUSE (1-1068): 0: 1314: 100.00
+	Mm
		500513 RRAS_MOUSE (13-177): 1.3e-52: 169: 57.58		PK3CA_MOUSE (1-1068): 0: 1314: 100.00
+	Hs
		348554 RASN_HUMAN (11-208): 6e-50: 162: 51.01		PK3CA_HUMAN (1-1068): 0: 1315: 98.69
+	Mm
		787349 RASH_MOUSE (11-178): 5.56e-50: 162: 56.55		PK3CA_MOUSE (1-1068): 0: 1314: 100.00
+	Mm
		193570 RRAS2_MOUSE (14-194): 5.37e-63: 196: 59.46		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Mm
		193565 RRAS_MOUSE (13-177): 1.3e-52: 169: 57.58		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Hs
		126186 RASH_HUMAN (11-178): 5.56e-50: 162: 56.55		PK3CD_HUMAN (1-1065): 0: 1167: 39.72
+	Mm
		193571 RASH_MOUSE (11-178): 5.56e-50: 162: 56.55		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Mm
		1142560 RASH_MOUSE (11-178): 5.56e-50: 162: 56.55		PK3CB_MOUSE (1-1065): 0: 1070: 38.57
+	Dm
		381632 RAS2_DROME (11-191): 1.38e-58: 184: 57.30		P91634_DROME (7-1065): 0: 954: 34.49
+	Dm
		442990 RAS1_DROME (11-191): 2.47e-52: 168: 55.25		P91634_DROME (7-1065): 0: 954: 34.49
+	Mm
		905466 RRAS2_MOUSE (14-194): 5.37e-63: 196: 59.46		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Mm
		500516 RRAS_MOUSE (13-177): 1.3e-52: 169: 57.58		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Mm
		1142568 RASH_MOUSE (11-178): 5.56e-50: 162: 56.55		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Hs
		348567 RASN_HUMAN (11-208): 6e-50: 162: 51.01		PK3CG_HUMAN (1-1062): 0: 891: 31.81
+	Sc
		350847 YPT1_YEAST (6-205): 1.74e-83: 248: 34.62		VPS34_YEAST (457-1065): 7.71e-163: 505: 25.37
+	Hs
		914106 RB11A_HUMAN (1-205): 3.89e-78: 234: 28.57		Q4LE69_HUMAN (562-1066): 1.48e-139: 466: 25.23
+	Hs
		348701 RASN_HUMAN (11-208): 6e-50: 162: 51.01		Q4LE69_HUMAN (562-1066): 1.48e-139: 466: 25.23
+	Hs
		896692 RAB14_HUMAN (1-203): 2.94e-79: 237: 29.41		PI4KB_HUMAN (798-1067): 2.21e-85: 295: 27.84
+	Hs
		914426 RB11A_HUMAN (1-205): 3.89e-78: 234: 28.57		PI4KB_HUMAN (798-1067): 2.21e-85: 295: 27.84