HitPredict

Interactor 1: LTBP2 (O08999)
Latent-transforming growth factor beta-binding protein 2 (LTBP-2)
Gene: LTBP2

Interactor 2: FBLN5 (Q9WVH9)
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance)
Gene: FBLN5

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17581631
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EGF~EGF_CA, EGF_CA~EGF_CA, EGF_CA~TB
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1813 Mm			1 448
+	Hs
		1059111 LTBP2_HUMAN (1-1813): 0: 648: 78.08		FBLN5_HUMAN (1-448): 6.2e-77: 248: 94.20
+	Hs
		724371 LTBP2_HUMAN (1-1813): 0: 648: 78.08		FBN2_HUMAN (22-288): 2.38e-16: 84: 24.32
+	Hs
		1059076 LTBP2_HUMAN (1-1813): 0: 648: 78.08		LTBP4_HUMAN (219-373): 5.15e-14: 76.8: 23.46
+	Hs
		980576 NOTC3_HUMAN (92-1432): 2.79e-78: 290: 14.54		NOTC2_HUMAN (4-341): 2.88e-15: 80.6: 11.39
+	Hs
		612912 NOTC3_HUMAN (92-1432): 2.79e-78: 290: 14.54		FBLN1_HUMAN (27-401): 6.14e-14: 76: 18.24
+	Hs
		1059044 NOTC3_HUMAN (92-1432): 2.79e-78: 290: 14.54		LTBP1_HUMAN (10-291): 1.4e-12: 72.1: 19.54
+	Dr
		804161 NOTC1_DANRE (200-1299): 6.43e-58: 224: 15.64		Q1A5L2_DANRE (5-165): 1.28e-14: 78.7: 13.04
+	Dm
		422709 NOTCH_DROME (201-1227): 3.01e-49: 196: 13.27		NOTCH_DROME (4-375): 8.63e-22: 101: 14.65
+	Dm
		90684 NOTCH_DROME (201-1227): 3.01e-49: 196: 13.27		E1JHA6_DROME (2-137): 9.86e-09: 60.2: 14.71
+	Dm
		114000 M9PB30_DROME (255-1394): 3.18e-24: 114: 11.89		CUBN_DROME (157-405): 5.54e-29: 122: 17.79
+	Hs
		957262 FBLN2_HUMAN (522-969): 2.91e-20: 100: 19.79		FBLN2_HUMAN (79-399): 2.88e-18: 89.9: 19.53
+	Hs
		235015 CUBN_HUMAN (1177-1545): 4.75e-19: 97.1: 29.05		CUBN_HUMAN (4-165): 1.93e-17: 87.5: 14.72
+	Hs
		1016997 LTBP3_HUMAN (117-921): 1.82e-20: 101: 9.64		FBLN3_HUMAN (3-190): 2.6e-16: 82.9: 23.83
+	Hs
		957265 FBLN2_HUMAN (522-969): 2.91e-20: 100: 19.79		FBLN3_HUMAN (3-190): 2.6e-16: 82.9: 23.83
+	Hs
		980578 JAG2_HUMAN (188-833): 1.14e-20: 101: 10.21		NOTC2_HUMAN (4-341): 2.88e-15: 80.6: 11.39
+	Hs
		724367 NOTC2_HUMAN (195-851): 3.99e-19: 97.1: 9.06		FBN2_HUMAN (22-288): 2.38e-16: 84: 24.32
+	Hs
		612843 NOTC2_HUMAN (195-851): 3.99e-19: 97.1: 9.06		FBLN1_HUMAN (27-401): 6.14e-14: 76: 18.24
+	Hs
		957267 FBLN2_HUMAN (522-969): 2.91e-20: 100: 19.79		LTBP1_HUMAN (10-291): 1.4e-12: 72.1: 19.54
+	Hs
		724337 FBLN2_HUMAN (522-969): 2.91e-20: 100: 19.79		FBN1_HUMAN (24-235): 3.75e-11: 67.8: 25.56