HitPredict

Interactor 1: HDAC1 (O09106)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: H4 (P62806)
Histone H4
Gene: H4c1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22441348
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 482 Mm			1 103
+	Hs
		917226 HDAC1_HUMAN (1-482): 0: 666: 99.38		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917682 HDAC2_HUMAN (1-478): 0: 664: 86.13		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Mm
		918237 HDAC2_MOUSE (1-478): 0: 663: 85.92		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Dm
		950398 HDAC1_DROME (6-477): 0: 656: 77.33		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	At
		886854 HDA6_ARATH (6-461): 0: 576: 58.61		H4_ARATH (1-103): 3.47e-48: 150: 98.06
+	Hs
		177252 HDAC3_HUMAN (9-434): 0: 572: 58.18		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356336 RPD3_YEAST (8-421): 0: 578: 61.48		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sp
		140573 PHD1_SCHPO (7-415): 0: 521: 53.40		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Sc
		356604 HOS2_YEAST (10-411): 1.26e-170: 489: 50.00		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917872 HDAC8_HUMAN (32-371): 4.46e-139: 406: 43.11		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356643 HDA1_YEAST (8-329): 6.41e-120: 368: 27.27		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		918077 HDAC6_HUMAN (16-325): 3.43e-93: 308: 25.78		H4_HUMAN (1-103): 1.38e-48: 151: 100.00