HitPredict

Interactor 1: HDAC1 (O09106)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: NSD2 (Q8BVE8)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Wolf-Hirschhorn syndrome candidate 1 protein homolog)
Gene: NSD2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	19483677
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 1365
+	Hs
		331809 HDAC1_HUMAN (1-482): 0: 666: 99.38		NSD2_HUMAN (1-1365): 0: 1003: 90.92
+	Hs
		331858 HDAC2_HUMAN (1-478): 0: 664: 86.13		NSD2_HUMAN (1-1365): 0: 1003: 90.92
+	Mm
		140205 HDAC1_MOUSE (1-482): 0: 670: 100.00		SUV91_MOUSE (829-1203): 1.42e-70: 244: 19.63
+	Hs
		203679 HDAC1_HUMAN (1-482): 0: 666: 99.38		SUV91_HUMAN (829-1203): 1.63e-70: 244: 20.19
+	Hs
		203750 HDAC2_HUMAN (1-478): 0: 664: 86.13		SUV91_HUMAN (829-1203): 1.63e-70: 244: 20.19
+	Mm
		222461 HDAC2_MOUSE (1-478): 0: 663: 85.92		SUV91_MOUSE (829-1203): 1.42e-70: 244: 19.63
+	Hs
		1038412 HDAC1_HUMAN (1-482): 0: 666: 99.38		EZH2_HUMAN (926-1188): 1.63e-61: 227: 23.55
+	Hs
		1080187 HDAC2_HUMAN (1-478): 0: 664: 86.13		EZH2_HUMAN (926-1188): 1.63e-61: 227: 23.55
+	Mm
		936404 HDAC2_MOUSE (1-478): 0: 663: 85.92		Q6AXH7_MOUSE (926-1188): 1.68e-61: 227: 23.55
+	Dm
		800656 HDAC1_DROME (6-477): 0: 656: 77.33		SUV39_DROME (863-1202): 8.98e-61: 223: 20.89
+	Hs
		1038631 HDAC1_HUMAN (1-482): 0: 666: 99.38		EHMT2_HUMAN (892-1216): 8.25e-55: 212: 20.11
+	Hs
		1038721 HDAC1_HUMAN (1-482): 0: 666: 99.38		EHMT1_HUMAN (906-1219): 9.69e-55: 212: 21.41
+	Mm
		140274 HDAC1_MOUSE (1-482): 0: 670: 100.00		EZH2_MOUSE (921-1188): 8.08e-55: 207: 22.78
+	Hs
		1270381 HDAC2_HUMAN (1-478): 0: 664: 86.13		EHMT2_HUMAN (892-1216): 8.25e-55: 212: 20.11
+	Hs
		1270450 HDAC2_HUMAN (1-478): 0: 664: 86.13		EHMT1_HUMAN (906-1219): 9.69e-55: 212: 21.41
+	Dm
		785632 HDAC1_DROME (6-477): 0: 656: 77.33		EZ_DROME (946-1191): 9.53e-55: 207: 23.64
+	Hs
		975244 HDAC1_HUMAN (1-482): 0: 666: 99.38		KMT2A_HUMAN (1055-1203): 1.69e-43: 176: 34.00
+	Hs
		1038822 HDAC1_HUMAN (1-482): 0: 666: 99.38		KMT2B_HUMAN (1049-1203): 8.73e-43: 174: 32.05
+	Hs
		975297 HDAC2_HUMAN (1-478): 0: 664: 86.13		KMT2A_HUMAN (1055-1203): 1.69e-43: 176: 34.00
+	Hs
		152639 HDAC1_HUMAN (1-482): 0: 666: 99.38		KMT2D_HUMAN (84-666): 1.38e-11: 71.9: 10.34