HitPredict

Interactor 1: HDAC1 (O09106)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: TF7L1 (Q9Z1J1)
Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3) (mTCF-3)
Gene: Tcf7l1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24463605
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 584
+	Mm
		140309 HDAC1_MOUSE (1-482): 0: 670: 100.00		TF7L2_MOUSE (34-453): 9.74e-52: 185: 63.55
+	Mm
		936421 HDAC2_MOUSE (1-478): 0: 663: 85.92		TF7L2_MOUSE (34-453): 9.74e-52: 185: 63.55
+	Rn
		1118086 HDAC1_RAT (1-482): 0: 670: 99.79		LEF1_RAT (28-441): 1.84e-44: 164: 47.14
+	Xl
		1193361 Q7ZYT5_XENLA (1-482): 0: 692: 90.66		Q90ZB8_XENLA (28-441): 1.23e-36: 142: 44.63
+	Hs
		1038795 HDAC1_HUMAN (1-482): 0: 666: 99.38		LEF1_HUMAN (28-441): 2.96e-44: 163: 47.86
+	Hs
		727863 HDAC1_HUMAN (1-482): 0: 666: 99.38		SOX6_HUMAN (90-498): 2.83e-41: 161: 15.69
+	Hs
		727903 HDAC2_HUMAN (1-478): 0: 664: 86.13		SOX6_HUMAN (90-498): 2.83e-41: 161: 15.69
+	Hs
		1038578 HDAC1_HUMAN (1-482): 0: 666: 99.38		BBX_HUMAN (330-559): 4.02e-37: 149: 17.83
+	Hs
		1038736 HDAC1_HUMAN (1-482): 0: 666: 99.38		HM20A_HUMAN (242-555): 1.18e-37: 144: 11.28
+	Hs
		1270459 HDAC2_HUMAN (1-478): 0: 664: 86.13		HM20A_HUMAN (242-555): 1.18e-37: 144: 11.28
+	Hs
		1038764 HDAC1_HUMAN (1-482): 0: 666: 99.38		HM20B_HUMAN (273-541): 6.96e-37: 141: 12.32
+	Hs
		1270484 HDAC2_HUMAN (1-478): 0: 664: 86.13		HM20B_HUMAN (273-541): 6.96e-37: 141: 12.32
+	Hs
		1038645 HDAC1_HUMAN (1-482): 0: 666: 99.38		CIC_HUMAN (44-581): 3.08e-32: 135: 13.37
+	Mm
		140273 HDAC1_MOUSE (1-482): 0: 670: 100.00		Q60I23_MOUSE (310-566): 5.19e-33: 130: 18.61
+	Hs
		1270390 HDAC2_HUMAN (1-478): 0: 664: 86.13		CIC_HUMAN (44-581): 3.08e-32: 135: 13.37
+	Mm
		140241 HDAC1_MOUSE (1-482): 0: 670: 100.00		SOX2_MOUSE (310-566): 9.83e-33: 129: 18.61
+	Hs
		818023 HDAC1_HUMAN (1-482): 0: 666: 99.38		SOX2_HUMAN (315-566): 1.52e-33: 132: 18.58
+	Hs
		818314 HDAC2_HUMAN (1-478): 0: 664: 86.13		SOX2_HUMAN (315-566): 1.52e-33: 132: 18.58
+	Mm
		936399 HDAC2_MOUSE (1-478): 0: 663: 85.92		Q60I23_MOUSE (310-566): 5.19e-33: 130: 18.61
+	Mm
		818688 HDAC2_MOUSE (1-478): 0: 663: 85.92		SOX2_MOUSE (310-566): 9.83e-33: 129: 18.61