Interactor 1: ACACB (O00763)
Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta)
Gene: ACACB
Interactor 2: BPL1 (P50747)
Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]
Gene: HLCS
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.55 | 0.90 | 0.708 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20085763 |
| Identification Methods | x-ray crystallography, enzymatic study, nuclear magnetic resonance |
| Interaction Type | association, direct interaction, enzymatic reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BPL_C~Biotin_lipoyl, BPL_LplA_LipB~Biotin_lipoyl |
| Common GO terms | GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0009374 - biotin binding |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
