HitPredict

Interactor 1: CUL4 (O14122)
Cullin-4 (Cul-4)
Gene: pcu4

Interactor 2: RIK1 (Q10426)
Chromatin modification-related protein rik1 (Silencing protein rik1)
Gene: RIK1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	24449894, 16127433, 16024659, 17114925
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms	GO:0005634 - nucleus GO:0043494 - CLRC complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 734 Sp			1 1040
+	Hs
		1043013 CUL4A_HUMAN (5-732): 0: 798: 31.97		DDB1_HUMAN (3-1024): 0: 1069: 17.36
+	Mm
		1111812 CUL4A_MOUSE (3-732): 0: 793: 31.47		DDB1_MOUSE (3-1024): 0: 1070: 17.36
+	Mm
		56795 CUL4B_MOUSE (2-732): 0: 791: 33.33		DDB1_MOUSE (3-1024): 0: 1070: 17.36
+	Hs
		1043374 CUL4B_HUMAN (2-732): 0: 790: 33.47		DDB1_HUMAN (3-1024): 0: 1069: 17.36
+	Hs
		1041668 CUL3_HUMAN (7-733): 0: 767: 25.65		DDB1_HUMAN (3-1024): 0: 1069: 17.36
+	At
		1228145 CUL4_ARATH (1-733): 0: 773: 32.07		DDB1A_ARATH (3-1024): 0: 1043: 18.89
+	At
		221829 CUL4_ARATH (1-733): 0: 773: 32.07		DDB1B_ARATH (3-1024): 0: 1036: 18.91
+	Hs
		1041008 CUL1_HUMAN (26-733): 0: 719: 22.38		DDB1_HUMAN (3-1024): 0: 1069: 17.36
+	Hs
		1043002 CUL4A_HUMAN (5-732): 0: 798: 31.97		SF3B3_HUMAN (3-1026): 0: 982: 13.64
+	Hs
		1041634 CUL3_HUMAN (7-733): 0: 767: 25.65		SF3B3_HUMAN (3-1026): 0: 982: 13.64
+	Dm
		1124382 Q5BI50_DROME (2-732): 0: 789: 32.07		DDB1_DROME (3-1024): 0: 940: 16.32
+	Hs
		1040995 CUL1_HUMAN (26-733): 0: 719: 22.38		SF3B3_HUMAN (3-1026): 0: 982: 13.64
+	Hs
		1041332 CUL2_HUMAN (24-733): 0: 686: 21.81		SF3B3_HUMAN (3-1026): 0: 982: 13.64
+	Hs
		1082313 CUL5_HUMAN (26-733): 0: 572: 19.95		DDB1_HUMAN (3-1024): 0: 1069: 17.36
+	Sp
		143266 CUL4_SCHPO (1-734): 0: 699: 100.00		DDB1_SCHPO (1-1039): 0: 834: 19.74
+	Ce
		1088892 CUL4_CAEEL (5-733): 0: 584: 25.49		DDB1_CAEEL (1-1024): 0: 812: 17.43
+	Hs
		1014118 CUL4A_HUMAN (5-732): 0: 798: 31.97		CPSF1_HUMAN (319-500): 9.9e-27: 120: 13.22
+	Hs
		1014117 CUL3_HUMAN (7-733): 0: 767: 25.65		CPSF1_HUMAN (319-500): 9.9e-27: 120: 13.22