HitPredict

Interactor 1: POP2 (O14170)
WD repeat-containing protein pop2 (Proteolysis factor sud1)
Gene: POP2

Interactor 2: SKP1 (Q9Y709)
Suppressor of kinetochore protein 1 (P19/Skp1 homolog)
Gene: SKP1

Species: Schizosaccharomyces pombe 972h-

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	12167173, 17016471, 15147268
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	F-box~Skp1
Common GO terms	GO:0005737 - cytoplasm GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0043224 - nuclear SCF ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 703 Sp			1 161
+	Sp
		953235 POP1_SCHPO (166-702): 7.94e-103: 333: 35.92		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Sp
		1000009 POF11_SCHPO (204-699): 3.36e-92: 297: 21.96		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Ce
		105479 SEL10_CAEEL (432-700): 5.63e-59: 211: 23.83		SKR1_CAEEL (3-160): 1.7e-78: 232: 56.10
+	Xl
		1174984 TRCB_XENLA (507-699): 3.96e-56: 201: 24.87		SKP1_XENLA (1-161): 9e-82: 240: 55.76
+	Mm
		1257397 FBXW7_MOUSE (529-700): 3.07e-43: 168: 24.44		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Hs
		929021 FBXW7_HUMAN (529-700): 3.93e-43: 168: 24.44		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Dm
		285042 FBXW7_DROME (235-468): 1.36e-35: 147: 10.55		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Sc
		759309 MET30_YEAST (533-700): 1.51e-41: 162: 25.73		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00
+	Sp
		953229 POF1_SCHPO (575-700): 1.71e-29: 125: 25.78		SKP1_SCHPO (1-161): 4.5e-81: 238: 100.00
+	Hs
		929125 FBW1A_HUMAN (577-701): 2.03e-27: 119: 23.02		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1112932 FBW1A_MOUSE (577-701): 1.07e-26: 117: 21.43		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Dm
		218244 O44382_DROME (575-701): 2.87e-27: 118: 20.46		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		285012 Q9VDE3_DROME (575-701): 3.2e-27: 118: 20.46		O77430_DROME (1-161): 5.17e-78: 230: 56.71
+	Dm
		1180601 Q9VDE3_DROME (575-701): 3.2e-27: 118: 20.46		Q7KJ69_DROME (1-161): 4.35e-74: 220: 53.37
+	Hs
		929116 FBXW2_HUMAN (583-692): 5.37e-18: 89.4: 22.52		SKP1_HUMAN (1-161): 9e-82: 240: 55.76
+	Mm
		1351515 Q9QUH1_MOUSE (583-692): 8.55e-18: 88.6: 23.42		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Ce
		105997 LIN23_CAEEL (578-701): 8.83e-26: 115: 20.80		G5EDD8_CAEEL (3-160): 3.13e-67: 203: 46.34
+	Sc
		431143 CDC4_YEAST (584-703): 2.14e-26: 117: 20.64		SKP1_YEAST (2-161): 5.56e-66: 201: 50.00
+	Mm
		1131317 FBW1B_MOUSE (618-699): 3.41e-14: 77.7: 16.87		SKP1_MOUSE (1-161): 8.42e-82: 240: 55.76
+	Dm
		1363661 Q9VDE3_DROME (575-701): 3.2e-27: 118: 20.46		Q9VWC4_DROME (2-151): 2.3e-65: 198: 47.71