HitPredict

Interactor 1: WIS4 (O14299)
MAP kinase kinase kinase wis4 (EC 2.7.11.25) (MAP kinase kinase kinase wak1) (MAP kinase kinase kinase wik1)
Gene: WIS4

Interactor 2: MCS4 (P87323)
Response regulator mcs4 (Mitotic catastrophe suppressor 4)
Gene: MCS4

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	11179424, 26771498, 18406331, 20946853, 23389634, 23695164
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:1990315 - Mcs4 RR-MAPKKK complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1401 Sp			1 522
+	Sp
		251222 WIN1_SCHPO (74-1306): 0: 1129: 35.98		MCS4_SCHPO (1-522): 0: 556: 100.00
+	Sc
		863048 SSK2_YEAST (78-1311): 0: 1064: 28.44		SSK1_YEAST (259-522): 7.01e-46: 172: 37.27
+	Sc
		764833 SSK2_YEAST (78-1311): 0: 1064: 28.44		SLN1_YEAST (215-504): 3.88e-38: 151: 24.04
+	Sc
		631051 SSK22_YEAST (146-1327): 0: 894: 26.13		SSK1_YEAST (259-522): 7.01e-46: 172: 37.27