HitPredict

Interactor 1: DLGP1 (O14490)
Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)
Gene: DLGAP1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	20936779, 17474147
Identification Methods	two hybrid, peptide array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Hs			1 217
+	Hs
		145936 DLGP1_HUMAN (1-977): 0: 1369: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		145931 DLGP1_HUMAN (1-977): 0: 1369: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		145955 DLGP1_HUMAN (1-977): 0: 1369: 100.00		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		145934 DLGP1_HUMAN (1-977): 0: 1369: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		145950 DLGP1_HUMAN (1-977): 0: 1369: 100.00		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		145935 DLGP1_HUMAN (1-977): 0: 1369: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		924914 DLGP2_HUMAN (1-977): 0: 1107: 51.91		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924968 DLGP4_HUMAN (1-977): 0: 1091: 47.27		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557812 DLGP2_HUMAN (1-977): 0: 1107: 51.91		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337576 DLGP2_HUMAN (1-977): 0: 1107: 51.91		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		557837 DLGP4_HUMAN (1-977): 0: 1091: 47.27		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337600 DLGP4_HUMAN (1-977): 0: 1091: 47.27		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412385 DLGP2_HUMAN (1-977): 0: 1107: 51.91		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		523179 DLGP2_HUMAN (1-977): 0: 1107: 51.91		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		412415 DLGP4_HUMAN (1-977): 0: 1091: 47.27		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		523220 DLGP4_HUMAN (1-977): 0: 1091: 47.27		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		327225 DLGP3_HUMAN (1-977): 0: 1015: 38.48		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		327221 DLGP3_HUMAN (1-977): 0: 1015: 38.48		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		327222 DLGP3_HUMAN (1-977): 0: 1015: 38.48		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		327223 DLGP3_HUMAN (1-977): 0: 1015: 38.48		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58