HitPredict

Interactor 1: DLGP1 (O14490)
Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)
Gene: DLGAP1

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.701

Property	Details
Experiments	9286858, 11060025, 9024696, 9115257
Identification Methods	two hybrid, affinity chromatography technology, pull down, far western blotting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0060090 - molecular adaptor activity GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Hs			1 904
+	Mm
		1195008 DLGP1_MOUSE (1-977): 0: 1336: 92.65		DLG1_MOUSE (1-904): 0: 720: 95.47
+	Rn
		956989 DLGP1_RAT (1-977): 0: 1334: 92.65		DLG1_RAT (1-904): 0: 701: 92.54
+	Hs
		145952 DLGP1_HUMAN (1-977): 0: 1369: 100.00		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Mm
		936189 DLGP1_MOUSE (1-977): 0: 1336: 92.65		DLG3_MOUSE (99-904): 0: 589: 64.69
+	Rn
		956990 DLGP1_RAT (1-977): 0: 1334: 92.65		DLG3_RAT (99-904): 0: 590: 64.57
+	Hs
		1021580 DLGP2_HUMAN (1-977): 0: 1107: 51.91		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		4617 A0A1B0GTN4_HUMAN (1-977): 0: 1107: 51.91		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		4619 A0A1B0GTN4_HUMAN (1-977): 0: 1107: 51.91		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Hs
		145945 DLGP1_HUMAN (1-977): 0: 1369: 100.00		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		145949 DLGP1_HUMAN (1-977): 0: 1369: 100.00		DLG2_HUMAN (393-627): 7.26e-21: 100: 24.48
+	Mm
		251107 DLGP1_MOUSE (1-977): 0: 1336: 92.65		CSKP_MOUSE (19-360): 4.37e-28: 123: 10.64
+	Mm
		1143504 DLGP1_MOUSE (1-977): 0: 1336: 92.65		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Rn
		677775 DLGP1_RAT (1-977): 0: 1334: 92.65		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Mm
		1265187 DLGP1_MOUSE (1-977): 0: 1336: 92.65		DLG2_MOUSE (393-627): 3.09e-21: 101: 24.48
+	Rn
		956992 DLGP1_RAT (1-977): 0: 1334: 92.65		DLG2_RAT (393-627): 2.93e-21: 101: 24.48
+	Hs
		159281 DLGP2_HUMAN (1-977): 0: 1107: 51.91		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Hs
		4613 A0A1B0GTN4_HUMAN (1-977): 0: 1107: 51.91		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Hs
		942392 DLGP2_HUMAN (1-977): 0: 1107: 51.91		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		1077291 DLGP2_HUMAN (1-977): 0: 1107: 51.91		DLG2_HUMAN (393-627): 7.26e-21: 100: 24.48
+	Hs
		4618 A0A1B0GTN4_HUMAN (1-977): 0: 1107: 51.91		MPP7_HUMAN (96-459): 7.98e-17: 86.8: 14.80