HitPredict

Interactor 1: DLGP1 (O14490)
Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)
Gene: DLGAP1

Interactor 2: SHAN1 (Q9Y566)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
Gene: SHANK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12954649
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0044877 - protein-containing complex binding GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 977 Hs			1 2161
+	Mm
		88376 DLGP1_MOUSE (1-977): 0: 1336: 92.65		SHAN1_MOUSE (1-2161): 3.12e-146: 507: 93.09
+	Rn
		956998 DLGP1_RAT (1-977): 0: 1334: 92.65		SHAN1_RAT (1-2161): 1.09e-145: 506: 92.77
+	Rn
		957003 DLGP2_RAT (1-977): 0: 1091: 50.97		SHAN1_RAT (1-2161): 1.09e-145: 506: 92.77
+	Mm
		1194593 DLGP1_MOUSE (1-977): 0: 1336: 92.65		SHAN2_MOUSE (1095-2161): 2.52e-47: 189: 16.62
+	Hs
		145956 DLGP1_HUMAN (1-977): 0: 1369: 100.00		SHAN2_HUMAN (683-2161): 4.9e-36: 152: 12.70
+	Rn
		956997 DLGP1_RAT (1-977): 0: 1334: 92.65		SHAN2_RAT (1095-2161): 1.43e-46: 187: 16.87
+	Hs
		145954 DLGP1_HUMAN (1-977): 0: 1369: 100.00		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Mm
		1116115 DLGP1_MOUSE (1-977): 0: 1336: 92.65		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Rn
		956996 DLGP1_RAT (1-977): 0: 1334: 92.65		SHAN3_RAT (297-1863): 8.52e-19: 96.2: 12.70
+	Hs
		1349917 DLGP2_HUMAN (1-977): 0: 1107: 51.91		SHAN2_HUMAN (683-2161): 4.9e-36: 152: 12.70
+	Hs
		1357785 DLGP4_HUMAN (1-977): 0: 1091: 47.27		SHAN2_HUMAN (683-2161): 4.9e-36: 152: 12.70
+	Mm
		1116003 DLGP2_MOUSE (1-977): 0: 1102: 51.36		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Hs
		1316300 DLGP2_HUMAN (1-977): 0: 1107: 51.91		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Hs
		1316315 DLGP4_HUMAN (1-977): 0: 1091: 47.27		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Mm
		69915 DLGP4_MOUSE (1-977): 0: 1073: 46.48		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Hs
		327248 DLGP3_HUMAN (1-977): 0: 1015: 38.48		SHAN2_HUMAN (683-2161): 4.9e-36: 152: 12.70
+	Hs
		327247 DLGP3_HUMAN (1-977): 0: 1015: 38.48		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Mm
		1115961 DLGP3_MOUSE (1-977): 0: 1007: 38.89		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Rn
		102520 G3V7T8_RAT (1-977): 0: 1002: 38.89		SHAN3_RAT (297-1863): 8.52e-19: 96.2: 12.70