HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 1210
+	Hs
		145979 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		145964 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		339155 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		339025 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338432 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		1071028 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		1071020 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		384032 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383994 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		602029 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		602010 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		383806 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		145966 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Mm
		546279 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65
+	Hs
		434194 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		411504 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		411384 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Mm
		710132 GRB7_MOUSE (4-511): 3.78e-90: 291: 13.96		FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68
+	Hs
		435774 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47
+	Dm
		382213 Q7K137_DROME (22-527): 4.32e-81: 272: 28.20		EGFR_DROME (30-339): 1.78e-25: 116: 21.28