HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 1255
+	Hs
		384032 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383994 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		145979 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		145963 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		1071028 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		1071020 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		339155 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		339025 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		602029 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		602010 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		145961 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Hs
		145966 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Rn
		1144006 SH2B1_RAT (1-631): 3.94e-95: 310: 33.25		JAK2_RAT (216-982): 1.86e-137: 450: 19.75
+	Mm
		1143573 SH2B1_MOUSE (1-631): 7.7e-95: 309: 33.95		JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53
+	Hs
		238446 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Hs
		238440 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Mm
		140162 SH2B3_MOUSE (23-630): 9.84e-94: 301: 30.83		JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53
+	Hs
		411504 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Mm
		546279 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		INSR_MOUSE (357-634): 8.32e-17: 88.7: 19.54
+	Hs
		435774 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92