HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	25921289, 9856458
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 796
+	Mm
		1143162 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		FGFR3_MOUSE (195-794): 0: 544: 26.42
+	Hs
		385574 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		NTRK1_HUMAN (1-796): 0: 621: 100.00
+	Rn
		728446 SH2B1_RAT (1-631): 3.94e-95: 310: 33.25		NTRK1_RAT (1-796): 0: 592: 85.61
+	Hs
		1083902 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72
+	Rn
		728440 SH2B3_RAT (386-630): 2.06e-69: 231: 33.57		NTRK1_RAT (1-796): 0: 592: 85.61
+	Hs
		609561 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98
+	Hs
		507999 GRB14_HUMAN (5-511): 4.67e-68: 233: 14.40		FGFR1_HUMAN (195-794): 0: 545: 26.34
+	Hs
		145966 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		412008 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55
+	Hs
		145974 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		LTK_HUMAN (502-790): 3.09e-60: 221: 41.64
+	Mm
		546279 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		INSR_MOUSE (493-777): 3.11e-66: 241: 41.95
+	Hs
		434194 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		RET_HUMAN (391-794): 3.5e-114: 374: 30.44
+	Hs
		872614 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		EPHB1_HUMAN (409-788): 1.23e-112: 367: 30.47
+	Hs
		412036 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64
+	Hs
		435774 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		411504 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Hs
		411384 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		INSR_HUMAN (493-777): 3e-68: 248: 42.62
+	Dm
		448244 Q7K137_DROME (22-527): 4.32e-81: 272: 28.20		INSR_DROME (495-782): 2.38e-63: 233: 40.54
+	Hs
		435642 GRB14_HUMAN (5-511): 4.67e-68: 233: 14.40		IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61
+	Hs
		411383 GRB14_HUMAN (5-511): 4.67e-68: 233: 14.40		INSR_HUMAN (493-777): 3e-68: 248: 42.62