HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	17620296, 15031295
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 1382
+	Mm
		546279 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		INSR_MOUSE (1-1382): 0: 1509: 94.36
+	Hs
		411504 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		411384 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		INSR_HUMAN (1-1382): 0: 1530: 100.00
+	Hs
		435774 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Dm
		448244 Q7K137_DROME (22-527): 4.32e-81: 272: 28.20		INSR_DROME (30-1382): 0: 1002: 34.55
+	Hs
		872614 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		EPHB1_HUMAN (571-1318): 0: 569: 21.86
+	Hs
		145964 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		145974 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		LTK_HUMAN (1013-1291): 2e-71: 259: 44.52
+	Hs
		145965 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		384032 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		383994 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		383806 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67
+	Hs
		1083902 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		NTRK2_HUMAN (996-1292): 3.55e-70: 254: 43.38
+	Hs
		385574 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Rn
		728446 SH2B1_RAT (1-631): 3.94e-95: 310: 33.25		NTRK1_RAT (996-1286): 4.48e-67: 245: 41.95
+	Hs
		609561 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78
+	Dm
		1360390 SRC42_DROME (298-623): 4.67e-71: 240: 15.02		CAD96_DROME (1014-1295): 1.07e-63: 234: 40.56
+	Hs
		602029 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		602010 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		601921 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11