HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: HCK (P08631)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Gene: HCK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.61 1.00 0.783

The method score is based on:

Property Details
Experiments 32296183, unassigned1304
Identification Methods two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
GO:0035556 - intracellular signal transduction
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 632
Hs

1 526
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024