HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	9989826
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 1106
+	Mm
		404018 SH2B1_MOUSE (1-631): 7.7e-95: 309: 33.95		PGFRB_MOUSE (1-1106): 0: 801: 85.44
+	Hs
		452424 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		PGFRB_HUMAN (1-1106): 0: 795: 100.00
+	Mm
		404012 FYN_MOUSE (275-623): 3.64e-67: 230: 13.61		PGFRB_MOUSE (1-1106): 0: 801: 85.44
+	Hs
		452423 GRB14_HUMAN (5-511): 4.67e-68: 233: 14.40		PGFRB_HUMAN (1-1106): 0: 795: 100.00
+	Hs
		411953 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		PGFRB_HUMAN (1-1106): 0: 795: 100.00
+	Hs
		499293 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Mm
		403544 SH2B1_MOUSE (1-631): 7.7e-95: 309: 33.95		KIT_MOUSE (24-1004): 0: 603: 31.01
+	Hs
		499267 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Hs
		411962 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Hs
		499272 TENS2_HUMAN (42-582): 2.77e-62: 226: 13.04		KIT_HUMAN (3-1003): 0: 601: 29.99
+	Hs
		412062 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		FLT3_HUMAN (21-1008): 7e-168: 522: 26.73
+	Mm
		1143162 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		FGFR3_MOUSE (25-334): 1.83e-53: 203: 11.40
+	Hs
		609561 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		FGFR3_HUMAN (1-313): 7.09e-52: 198: 10.66
+	Hs
		507999 GRB14_HUMAN (5-511): 4.67e-68: 233: 14.40		FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44
+	Hs
		412008 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		FGFR2_HUMAN (9-326): 2.34e-58: 218: 11.51
+	Hs
		411995 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47
+	Dm
		112231 SRC42_DROME (298-623): 4.67e-71: 240: 15.02		M9MRE1_DROME (32-503): 7e-43: 173: 16.67
+	Hs
		411943 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		CSF1R_HUMAN (10-385): 7.2e-13: 75.3: 12.97
+	Mm
		452181 FYN_MOUSE (275-623): 3.64e-67: 230: 13.61		CSF1R_MOUSE (19-304): 1.94e-12: 73.7: 11.84
+	Hs
		412060 FYN_HUMAN (275-622): 3.25e-67: 230: 13.65		VGFR2_HUMAN (10-197): 4.73e-11: 69.5: 11.31