HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 864
+	Hs
		145979 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Mm
		1143162 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		FGFR3_MOUSE (75-788): 1.96e-138: 432: 20.94
+	Hs
		145966 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Mm
		546279 SH2B2_MOUSE (1-632): 1.08e-152: 456: 80.82		INSR_MOUSE (380-799): 1.89e-109: 368: 32.31
+	Hs
		609561 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		FGFR3_HUMAN (100-834): 2.96e-137: 429: 20.99
+	Hs
		1071028 SH2B3_HUMAN (23-630): 3.15e-98: 313: 28.87		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Hs
		1071020 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Hs
		435774 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		434194 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		RET_HUMAN (278-849): 5.71e-146: 461: 25.98
+	Hs
		411504 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		145965 SH2B2_HUMAN (22-632): 9.37e-163: 482: 100.00		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Hs
		1054054 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Hs
		872614 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		EPHB1_HUMAN (390-816): 1.59e-127: 409: 25.17
+	Hs
		411384 GRB7_HUMAN (4-511): 1.12e-80: 266: 13.77		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Mm
		710132 GRB7_MOUSE (4-511): 3.78e-90: 291: 13.96		FAK1_MOUSE (453-859): 5.41e-110: 363: 28.67
+	Hs
		411383 GRB14_HUMAN (5-511): 4.67e-68: 233: 14.40		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		1083902 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		NTRK2_HUMAN (475-778): 2.43e-61: 224: 38.07
+	Hs
		385574 SH2B1_HUMAN (1-631): 7.05e-96: 312: 33.77		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Rn
		728446 SH2B1_RAT (1-631): 3.94e-95: 310: 33.25		NTRK1_RAT (502-784): 2.42e-60: 221: 41.24
+	Dm
		448244 Q7K137_DROME (22-527): 4.32e-81: 272: 28.20		INSR_DROME (457-778): 1.88e-68: 250: 37.69