HitPredict

Interactor 1: BHE40 (O14503)
Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)
Gene: BHLHE40

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	25202122, 26091241, 28514442, 33961781
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0042752 - regulation of circadian rhythm GO:0043433 - negative regulation of DNA-binding transcription factor activity GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 605
+	Hs
		146554 BHE40_HUMAN (1-412): 1.61e-147: 426: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Mm
		1112924 BHE41_MOUSE (14-402): 6.31e-60: 202: 41.50		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		1354208 HEY2_HUMAN (15-333): 2.61e-52: 179: 14.63		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1319431 BHE41_HUMAN (14-290): 1.68e-43: 160: 46.69		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Mm
		1257392 HES6_MOUSE (37-275): 4.65e-39: 141: 21.16		FBXW7_MOUSE (76-527): 2.98e-83: 277: 23.71
+	Hs
		903499 BHE41_HUMAN (14-290): 1.68e-43: 160: 46.69		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Dm
		525762 ESM8_DROME (43-235): 6.74e-41: 145: 17.86		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37