HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	28883622
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 1257
+	Hs
		151689 LCK_HUMAN (1-172): 3.23e-43: 152: 15.63		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		147457 SOCS6_HUMAN (2-196): 4.82e-41: 147: 31.03		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151692 LYN_HUMAN (14-172): 3.22e-41: 147: 15.57		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151857 P55G_HUMAN (9-168): 3.07e-15: 74.8: 18.52		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Hs
		151716 P85A_HUMAN (14-161): 1.06e-14: 73.6: 18.54		IRS4_HUMAN (1-1257): 0: 1632: 100.00
+	Dm
		993227 GRAP_DROME (18-161): 2.09e-31: 115: 22.22		IRS1_DROME (83-354): 1.31e-71: 261: 30.00
+	Dm
		186292 O18683_DROME (24-158): 6.29e-18: 82.9: 25.19		IRS1_DROME (83-354): 1.31e-71: 261: 30.00
+	Mm
		639440 LYN_MOUSE (14-172): 1.34e-41: 148: 14.97		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		146670 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		147455 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		412057 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Hs
		147396 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Mm
		946348 GRB2_MOUSE (1-185): 4.98e-39: 134: 14.14		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		181903 SOCS1_HUMAN (32-198): 8.74e-41: 139: 31.77		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		181808 SOCS1_HUMAN (32-198): 8.74e-41: 139: 31.77		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Mm
		724599 GRB2_MOUSE (1-185): 4.98e-39: 134: 14.14		IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51
+	Mm
		643075 P85A_MOUSE (14-161): 9.75e-15: 73.6: 18.54		IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68
+	Hs
		1267462 P55G_HUMAN (9-168): 3.07e-15: 74.8: 18.52		IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82
+	Hs
		724554 P55G_HUMAN (9-168): 3.07e-15: 74.8: 18.52		IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17
+	Mm
		643063 P85A_MOUSE (14-161): 9.75e-15: 73.6: 18.54		IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51