HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	29559623, 9727029
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 1367
+	Hs
		147378 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		146667 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		147373 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Mm
		763386 FYN_MOUSE (14-172): 9.3e-47: 162: 14.97		EPHA4_MOUSE (655-1342): 0: 565: 23.54
+	Hs
		412036 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA3_HUMAN (666-1311): 0: 564: 24.96
+	Hs
		412105 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12
+	Hs
		146597 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93
+	Hs
		412104 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01
+	Hs
		412103 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHB3_HUMAN (661-1285): 4.29e-170: 536: 23.96
+	Hs
		412037 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87
+	Hs
		146632 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95
+	Hs
		146579 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Dm
		526800 Q8INY1_DROME (25-197): 7.24e-48: 168: 29.14		7LESS_DROME (993-1259): 6.81e-67: 252: 48.73
+	Hs
		412212 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95
+	Hs
		433229 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		147391 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44
+	Hs
		146593 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		433253 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		147390 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		433265 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		EPHB2_HUMAN (496-674): 6.85e-19: 95.5: 17.88