HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 976
+	Hs
		411962 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		433226 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		KIT_HUMAN (1-976): 0: 807: 100.00
+	Hs
		147381 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		KIT_HUMAN (1-976): 0: 807: 100.00
+	Mm
		404012 FYN_MOUSE (14-172): 9.3e-47: 162: 14.97		PGFRB_MOUSE (14-974): 0: 597: 29.51
+	Hs
		411953 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		433221 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		PGFRB_HUMAN (30-954): 0: 591: 30.62
+	Hs
		146603 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Mm
		193364 SOCS2_MOUSE (1-198): 3.15e-63: 196: 93.94		FLT3_MOUSE (11-968): 9.07e-170: 523: 30.16
+	Hs
		412062 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		433274 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		FLT3_HUMAN (11-968): 1.65e-171: 528: 29.98
+	Hs
		412008 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		FGFR2_HUMAN (8-323): 1.59e-55: 209: 13.10
+	Dm
		112231 SRC42_DROME (1-173): 5.16e-46: 160: 17.05		M9MRE1_DROME (31-495): 6.65e-36: 149: 17.32
+	Hs
		433229 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		FGFR1_HUMAN (4-235): 6.88e-22: 104: 13.25
+	Mm
		452181 FYN_MOUSE (14-172): 9.3e-47: 162: 14.97		CSF1R_MOUSE (6-304): 6.2e-18: 91.3: 13.53
+	Hs
		411995 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01
+	Hs
		412060 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		VGFR2_HUMAN (3-106): 1.62e-13: 77.5: 14.04
+	Hs
		433247 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		VGFR1_HUMAN (3-112): 1.99e-14: 80.2: 13.01
+	Hs
		411943 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10
+	Hs
		426975 YES_HUMAN (15-176): 1.6e-45: 159: 13.53		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10
+	Hs
		147375 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CSF1R_HUMAN (209-511): 1.03e-12: 74.4: 14.10