HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30945288
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 759
+	Hs
		337467 ABL1_HUMAN (3-173): 4.38e-42: 152: 19.65		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		789064 ABL2_HUMAN (3-173): 3.14e-42: 152: 18.50		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		147421 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		337468 ABL1_HUMAN (3-173): 4.38e-42: 152: 19.65		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		411713 LCK_HUMAN (1-172): 3.23e-43: 152: 15.63		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1041477 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		146642 SOCS2_HUMAN (1-198): 1.6e-64: 199: 100.00		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Mm
		193366 SOCS2_MOUSE (1-198): 3.15e-63: 196: 93.94		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Mm
		1257617 SOCS7_MOUSE (31-196): 2.38e-49: 170: 32.18		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Hs
		146692 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Hs
		147440 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Mm
		1143676 CISH_MOUSE (3-198): 1.55e-47: 157: 37.56		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Mm
		193394 SOCS3_MOUSE (25-194): 2.64e-47: 156: 29.15		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Hs
		256856 SOCS5_HUMAN (11-197): 2.72e-43: 153: 30.16		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Mm
		222648 SOCS5_MOUSE (11-197): 1.09e-42: 151: 29.63		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Hs
		1274062 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Mm
		1265273 SOCS4_MOUSE (13-197): 8.66e-42: 147: 27.81		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Hs
		147544 SOCS6_HUMAN (2-196): 4.82e-41: 147: 31.03		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Mm
		1322060 SOCS6_MOUSE (2-196): 1.63e-40: 145: 31.03		CUL5_MOUSE (59-759): 0: 589: 25.20
+	Hs
		1263831 SOCS4_HUMAN (14-197): 9.03e-41: 144: 27.96		CUL5_HUMAN (59-759): 0: 589: 24.94