HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 21980433
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 198 Hs			1 113
+	Hs
		146699 SOCS7_HUMAN (31-196): 1.96e-49: 170: 32.18		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		147449 SOCS3_HUMAN (25-194): 4.14e-48: 158: 29.15		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Mm
		193396 SOCS3_MOUSE (25-194): 2.64e-47: 156: 29.15		RBX2_MOUSE (1-113): 2.07e-33: 114: 96.46
+	Hs
		256860 SOCS5_HUMAN (11-197): 2.72e-43: 153: 30.16		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		181836 SOCS1_HUMAN (32-198): 8.74e-41: 139: 31.77		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		1345543 CISH_HUMAN (3-198): 4.83e-44: 149: 38.29		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		147569 SOCS6_HUMAN (2-196): 4.82e-41: 147: 31.03		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1263837 SOCS4_HUMAN (14-197): 9.03e-41: 144: 27.96		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		412267 FYN_HUMAN (14-172): 9.8e-47: 162: 14.97		RN149_HUMAN (44-112): 2.28e-17: 77.5: 24.64