Interactor 1: NRG2 (O14511)
Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]
Gene: NRG2

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 0.60 0.602

The method score is based on:

Property Details
Experiments 15358134, 9168115
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007399 - nervous system development
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 850
Hs

1 1308
+ Rn
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+ Rn
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+ Hs
+ Hs
+ Hs
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+ Gg
+ Dm
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024