HitPredict

Interactor 1: SOCS7 (O14512)
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Gene: SOCS7

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	9344857, 33961781, 17803907
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 581 Hs			1 377
+	Hs
		146663 SOCS7_HUMAN (1-581): 0: 569: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		146666 SOCS7_HUMAN (1-581): 0: 569: 100.00		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		146674 SOCS7_HUMAN (1-581): 0: 569: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		146668 SOCS7_HUMAN (1-581): 0: 569: 100.00		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		789043 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		147488 SOCS6_HUMAN (346-553): 3.89e-58: 205: 46.19		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129140 SOCS6_HUMAN (346-553): 3.89e-58: 205: 46.19		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		655265 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		924732 SOCS4_HUMAN (354-568): 1.77e-57: 200: 26.98		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Mm
		643099 CRK_MOUSE (388-568): 1.13e-50: 178: 20.22		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Hs
		129237 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Mm
		140063 CRK_MOUSE (388-568): 1.13e-50: 178: 20.22		P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41
+	Hs
		522839 MATK_HUMAN (295-521): 4.63e-51: 185: 18.06		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		146582 SOCS2_HUMAN (366-554): 1.38e-58: 195: 30.73		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		522848 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		802558 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		782750 MATK_HUMAN (295-521): 4.63e-51: 185: 18.06		CSK_HUMAN (4-143): 1.92e-12: 70.2: 14.38
+	Hs
		129146 SOCS1_HUMAN (382-554): 2.8e-39: 144: 24.28		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		802689 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		181765 SOCS1_HUMAN (382-554): 2.8e-39: 144: 24.28		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39