HitPredict

Interactor 1: SOCS7 (O14512)
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Gene: SOCS7

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	15677474
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 581 Hs			1 770
+	Hs
		146672 SOCS7_HUMAN (1-581): 0: 569: 100.00		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		193377 SOCS3_MOUSE (382-551): 2.95e-37: 139: 25.13		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		147400 SOCS3_HUMAN (382-551): 2.92e-35: 134: 25.13		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		256851 SOCS5_HUMAN (248-565): 5.3e-66: 226: 20.30		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		655247 P85A_HUMAN (371-499): 2.26e-14: 78.5: 17.42		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776765 P55G_HUMAN (389-523): 3.91e-14: 76.9: 21.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		129229 P85B_HUMAN (389-493): 9.45e-14: 76.2: 23.59		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		802601 CRK_HUMAN (388-568): 5.06e-51: 179: 20.77		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Hs
		146609 SOCS2_HUMAN (366-554): 1.38e-58: 195: 30.73		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Mm
		786656 CISH_MOUSE (322-554): 5.42e-48: 169: 24.51		STA5A_MOUSE (1-734): 0: 757: 30.46
+	Hs
		849911 CISH_HUMAN (322-554): 5.68e-47: 167: 24.23		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786637 CISH_HUMAN (322-554): 5.68e-47: 167: 24.23		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		802809 CRKL_HUMAN (392-566): 1.61e-37: 142: 18.75		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786590 CRKL_HUMAN (392-566): 1.61e-37: 142: 18.75		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Dm
		1096415 Q8INY1_DROME (262-577): 1.78e-61: 218: 23.55		STAT_DROME (1-755): 0: 648: 22.58
+	Dm
		1096410 Q7JVF1_DROME (352-549): 4.42e-62: 210: 29.29		STAT_DROME (1-755): 0: 648: 22.58
+	Hs
		849903 P55G_HUMAN (389-523): 3.91e-14: 76.9: 21.32		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Mm
		193381 SOCS3_MOUSE (382-551): 2.95e-37: 139: 25.13		STAT6_MOUSE (1-761): 0: 668: 25.69