HitPredict

Interactor 1: SOCS7 (O14512)
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Gene: SOCS7

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	24210661, 28514442, 31253590, 33961781, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 581 Hs			1 780
+	Mm
		1257617 SOCS7_MOUSE (1-581): 0: 546: 96.39		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		256856 SOCS5_HUMAN (248-565): 5.3e-66: 226: 20.30		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		222648 SOCS5_MOUSE (248-565): 2.81e-62: 216: 20.00		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147544 SOCS6_HUMAN (346-553): 3.89e-58: 205: 46.19		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		1263831 SOCS4_HUMAN (354-568): 1.77e-57: 200: 26.98		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		146642 SOCS2_HUMAN (366-554): 1.38e-58: 195: 30.73		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1322060 SOCS6_MOUSE (333-553): 6.18e-56: 199: 43.61		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1265273 SOCS4_MOUSE (354-568): 1.5e-54: 192: 27.44		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193366 SOCS2_MOUSE (363-554): 1.91e-57: 192: 29.23		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1274062 CISH_HUMAN (322-554): 5.68e-47: 167: 24.23		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1143676 CISH_MOUSE (322-554): 5.42e-48: 169: 24.51		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146625 SOCS2_HUMAN (366-554): 1.38e-58: 195: 30.73		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		181885 SOCS1_HUMAN (382-554): 2.8e-39: 144: 24.28		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		147440 SOCS3_HUMAN (382-551): 2.92e-35: 134: 25.13		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193394 SOCS3_MOUSE (382-551): 2.95e-37: 139: 25.13		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193357 SOCS1_MOUSE (382-554): 3.93e-37: 138: 24.28		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147421 SOCS3_HUMAN (382-551): 2.92e-35: 134: 25.13		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041477 CISH_HUMAN (322-554): 5.68e-47: 167: 24.23		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		181856 SOCS1_HUMAN (382-554): 2.8e-39: 144: 24.28		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Dm
		186280 O18683_DROME (373-522): 1.24e-33: 136: 26.45		CUL1_DROME (3-780): 0: 694: 25.99