HitPredict

Interactor 1: CDKA1 (O14519)
Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor)
Gene: CDK2AP1

Interactor 2: CHD5 (Q8TDI0)
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)
Gene: CHD5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0016581 - NuRD complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 115 Hs			1 1954
+	Hs
		279811 CDKA2_HUMAN (19-115): 6.1e-40: 131: 66.00		CHD5_HUMAN (1-1954): 0: 1751: 100.00
+	Hs
		146812 CDKA1_HUMAN (1-115): 1.29e-60: 183: 100.00		CHD3_HUMAN (28-1952): 0: 1551: 66.72
+	Hs
		146817 CDKA1_HUMAN (1-115): 1.29e-60: 183: 100.00		CHD4_HUMAN (51-1916): 0: 1500: 70.29
+	Hs
		279797 CDKA2_HUMAN (19-115): 6.1e-40: 131: 66.00		CHD3_HUMAN (28-1952): 0: 1551: 66.72
+	Hs
		279803 CDKA2_HUMAN (19-115): 6.1e-40: 131: 66.00		CHD4_HUMAN (51-1916): 0: 1500: 70.29
+	Dm
		332908 Q9VZ27_DROME (37-114): 3.5e-27: 102: 58.97		CHDM_DROME (15-1942): 0: 1349: 49.51
+	Dm
		115148 M9PEA2_DROME (37-114): 1.29e-26: 101: 58.97		CHDM_DROME (15-1942): 0: 1349: 49.51
+	Hs
		146775 CDKA1_HUMAN (1-115): 1.29e-60: 183: 100.00		SMCA5_HUMAN (575-1643): 0: 743: 26.22
+	Hs
		146802 CDKA1_HUMAN (1-115): 1.29e-60: 183: 100.00		SMCA1_HUMAN (584-1628): 0: 724: 25.42