HitPredict

Interactor 1: DPYL4 (O14531)
Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4)
Gene: DPYSL4

Interactor 2: DPYL3 (Q14195)
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Gene: DPYSL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1
Common GO terms	GO:0005829 - cytosol GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0031005 - filamin binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 572 Hs			1 570
+	Hs
		1050861 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL3_HUMAN (1-570): 0: 765: 100.00
+	Hs
		1050916 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL3_HUMAN (1-570): 0: 765: 100.00
+	Hs
		1083118 DPYL2_HUMAN (1-571): 0: 760: 75.66		Q8IXW6_HUMAN (1-570): 0: 765: 99.83
+	Mm
		956446 DPYL1_MOUSE (1-571): 0: 756: 69.35		DPYL3_MOUSE (1-570): 0: 764: 98.42
+	Hs
		1050860 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL1_HUMAN (1-569): 0: 748: 74.43
+	Hs
		1050867 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL2_HUMAN (1-569): 0: 742: 76.71
+	Hs
		1083101 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL2_HUMAN (1-569): 0: 742: 76.71
+	Mm
		139071 DPYL2_MOUSE (1-571): 0: 759: 76.01		DPYL2_MOUSE (1-569): 0: 740: 77.41
+	Rn
		815101 DPYL2_RAT (1-571): 0: 759: 76.01		DPYL2_RAT (1-569): 0: 740: 77.41
+	Mm
		139110 DPYL2_MOUSE (1-571): 0: 759: 76.01		DPYL1_MOUSE (1-569): 0: 738: 74.43
+	Hs
		147331 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL4_HUMAN (1-570): 0: 730: 70.11
+	Hs
		147335 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL4_HUMAN (1-570): 0: 730: 70.11
+	Mm
		956442 DPYL1_MOUSE (1-571): 0: 756: 69.35		Q3TMU8_MOUSE (1-570): 0: 731: 70.11
+	Hs
		1083161 DPYL2_HUMAN (1-571): 0: 760: 75.66		X5DQV1_HUMAN (14-569): 0: 720: 74.19
+	Hs
		1048473 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYS_HUMAN (16-522): 0: 649: 58.90
+	Hs
		1083135 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL5_HUMAN (9-565): 0: 649: 50.71
+	Mm
		139196 DPYL2_MOUSE (1-571): 0: 759: 76.01		DPYL5_MOUSE (9-565): 0: 642: 50.54
+	Hs
		147330 DPYL4_HUMAN (1-572): 0: 751: 100.00		DPYS_HUMAN (16-522): 0: 649: 58.90