HitPredict

Interactor 1: DPYL4 (O14531)
Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4)
Gene: DPYSL4

Interactor 2: DPYL2 (Q16555)
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Gene: DPYSL2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	33961781, 21900206
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Amidohydro_1~Amidohydro_1
Common GO terms	GO:0005829 - cytosol GO:0007399 - nervous system development GO:0016812 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 572 Hs			1 572
+	Hs
		1050867 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL2_HUMAN (1-572): 0: 769: 100.00
+	Hs
		1083101 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL2_HUMAN (1-572): 0: 769: 100.00
+	Mm
		139071 DPYL2_MOUSE (1-571): 0: 759: 76.01		DPYL2_MOUSE (1-572): 0: 768: 98.78
+	Rn
		815101 DPYL2_RAT (1-571): 0: 759: 76.01		DPYL2_RAT (1-572): 0: 768: 98.78
+	Hs
		1050860 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL1_HUMAN (1-572): 0: 761: 76.22
+	Mm
		139110 DPYL2_MOUSE (1-571): 0: 759: 76.01		DPYL1_MOUSE (1-572): 0: 752: 76.22
+	Hs
		1050861 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL3_HUMAN (1-571): 0: 744: 76.71
+	Hs
		1050916 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL3_HUMAN (1-571): 0: 744: 76.71
+	Hs
		1083118 DPYL2_HUMAN (1-571): 0: 760: 75.66		Q8IXW6_HUMAN (1-571): 0: 743: 76.53
+	Hs
		147331 DPYL1_HUMAN (1-571): 0: 762: 69.18		DPYL4_HUMAN (1-571): 0: 740: 75.66
+	Mm
		956446 DPYL1_MOUSE (1-571): 0: 756: 69.35		DPYL3_MOUSE (1-571): 0: 743: 76.18
+	Mm
		956442 DPYL1_MOUSE (1-571): 0: 756: 69.35		Q3TMU8_MOUSE (1-571): 0: 740: 76.01
+	Hs
		1083161 DPYL2_HUMAN (1-571): 0: 760: 75.66		X5DQV1_HUMAN (14-572): 0: 733: 76.03
+	Hs
		1083135 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYL5_HUMAN (9-567): 0: 653: 51.34
+	Hs
		1048473 DPYL2_HUMAN (1-571): 0: 760: 75.66		DPYS_HUMAN (13-528): 0: 651: 59.04
+	Mm
		139196 DPYL2_MOUSE (1-571): 0: 759: 76.01		DPYL5_MOUSE (9-567): 0: 647: 50.62
+	Hs
		147330 DPYL4_HUMAN (1-572): 0: 751: 100.00		DPYS_HUMAN (13-528): 0: 651: 59.04