HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: PDPK1 (O15530)
3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
Gene: PDPK1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 556
+	Hs
		182106 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		PDPK1_HUMAN (1-556): 0: 563: 100.00
+	Hs
		412046 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		AKT1_HUMAN (46-410): 1.08e-141: 419: 31.35
+	Hs
		433609 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		AKT2_HUMAN (27-412): 5.21e-142: 420: 32.13
+	Hs
		522810 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		AKT1_HUMAN (46-410): 1.08e-141: 419: 31.35
+	Mm
		403418 SRC_MOUSE (35-219): 1.74e-45: 160: 17.13		AKT1_MOUSE (44-414): 7.3e-140: 415: 31.12
+	Hs
		411994 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		KAPCA_HUMAN (40-391): 7.05e-139: 407: 31.53
+	Hs
		412014 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		KAPCB_HUMAN (72-391): 6.83e-138: 405: 34.38
+	Dm
		1213395 Q9VGK8_DROME (3-220): 2.62e-39: 145: 13.55		AKT1_DROME (75-409): 2.54e-141: 423: 34.82
+	Hs
		412141 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		KPCT_HUMAN (3-380): 7.1e-132: 402: 31.27
+	Mm
		397197 SRC_MOUSE (35-219): 1.74e-45: 160: 17.13		KAPCA_MOUSE (40-391): 5.15e-138: 405: 31.25
+	Hs
		681710 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		AKT1_HUMAN (46-410): 1.08e-141: 419: 31.35
+	Hs
		411685 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		KPCT_HUMAN (3-380): 7.1e-132: 402: 31.27
+	Mm
		969031 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		KPCT_MOUSE (3-392): 3.66e-131: 400: 29.57
+	Hs
		181797 SOCS1_HUMAN (19-221): 4.01e-37: 130: 25.98		KAPCB_HUMAN (72-391): 6.83e-138: 405: 34.38
+	Mm
		654978 VAV_MOUSE (41-173): 3.65e-29: 116: 18.80		KPCT_MOUSE (3-392): 3.66e-131: 400: 29.57
+	Hs
		548689 VAV_HUMAN (41-173): 4.43e-27: 110: 18.05		KPCT_HUMAN (3-380): 7.1e-132: 402: 31.27
+	Hs
		412095 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		KS6A3_HUMAN (4-354): 3.18e-103: 328: 24.20
+	Hs
		129195 P85B_HUMAN (37-147): 1.75e-18: 85.6: 22.52		KAPCA_HUMAN (40-391): 7.05e-139: 407: 31.53
+	Hs
		522867 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		KS6A3_HUMAN (4-354): 3.18e-103: 328: 24.20
+	Dm
		337672 SRC64_DROME (34-223): 2.87e-42: 151: 16.00		KAPC1_DROME (80-353): 6.6e-59: 201: 37.59