HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.979

Property	Details
Experiments	24438103, 10882725, 10421843, 9344848, 11314018, 19543316, 22342841, 15514089, 14517242, 29752723, 36112698, 24354892
Identification Methods	enzymatic study, affinity chromatography technology, two hybrid, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0045597 - positive regulation of cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1132
+	Hs
		238424 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		JAK2_HUMAN (1-1132): 0: 1122: 100.00
+	Mm
		193387 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		JAK2_MOUSE (1-1129): 0: 1108: 93.89
+	Mm
		980968 YES_MOUSE (30-223): 1.41e-50: 173: 15.11		JAK2_MOUSE (1-1129): 0: 1108: 93.89
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (821-1131): 3.47e-94: 328: 32.05
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (811-1125): 8.72e-98: 322: 26.90
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (801-1132): 4.46e-98: 322: 29.13
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (811-1125): 8.72e-98: 322: 26.90
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (801-1132): 4.46e-98: 322: 29.13
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (811-1125): 8.72e-98: 322: 26.90
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (817-1125): 1.98e-96: 319: 28.07
+	Hs
		147406 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		BLK_HUMAN (795-1124): 2.46e-93: 309: 29.52
+	Hs
		433216 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LYN_HUMAN (793-1132): 2.7e-93: 309: 29.91
+	Hs
		433222 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGR_HUMAN (810-1125): 2.41e-91: 305: 26.81
+	Hs
		147422 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PTK6_HUMAN (839-1126): 9.96e-88: 292: 29.07
+	Hs
		147407 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		JAK3_HUMAN (545-829): 3.38e-62: 233: 20.97
+	Hs
		147392 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94
+	Mm
		69807 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		B1ASP2_MOUSE (792-1131): 1.77e-36: 151: 17.91
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (518-822): 4.52e-17: 89: 26.97
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (521-808): 2.52e-18: 93.2: 25.25
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (545-838): 5.95e-13: 75.5: 22.57