HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	25402006, 24658140, 12070153, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1210
+	Hs
		338763 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		337789 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		433359 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		147371 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383538 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		147390 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		433253 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Mm
		193373 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65
+	Hs
		146667 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		147373 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Hs
		433331 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Mm
		193375 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68
+	Hs
		147414 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		111145 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Hs
		433329 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		111147 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Hs
		147378 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47