HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21234523
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 509
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411559 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		LCK_HUMAN (1-509): 0: 661: 100.00
+	Mm
		411932 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LCK_MOUSE (1-509): 0: 657: 96.86
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		433231 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		SRC_HUMAN (20-507): 0: 586: 55.00
+	Mm
		536205 FGR_MOUSE (35-223): 1.31e-48: 168: 14.55		FGR_MOUSE (1-507): 0: 591: 53.19
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		433216 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		454794 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433222 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGR_HUMAN (1-507): 0: 579: 52.76
+	Hs
		433535 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		454787 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		FGR_HUMAN (1-507): 0: 579: 52.76
+	Hs
		147406 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		BLK_HUMAN (1-509): 0: 557: 59.35
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		337315 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		147402 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		TXK_HUMAN (61-500): 3.54e-162: 471: 37.64
+	Hs
		147422 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PTK6_HUMAN (63-499): 1.36e-161: 467: 40.41