HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	11071852
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1367
+	Mm
		193373 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		INSR_MOUSE (20-1365): 0: 1219: 56.40
+	Hs
		146667 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		147373 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Mm
		763386 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		EPHA4_MOUSE (655-1342): 0: 565: 23.54
+	Hs
		412036 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHA3_HUMAN (666-1311): 0: 564: 24.96
+	Hs
		412105 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12
+	Hs
		412104 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01
+	Hs
		412103 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHB3_HUMAN (661-1285): 4.29e-170: 536: 23.96
+	Hs
		412037 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87
+	Hs
		256861 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12
+	Hs
		147395 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10
+	Hs
		412212 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		NTRK2_HUMAN (977-1256): 2.65e-70: 255: 43.95
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54
+	Hs
		147391 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44
+	Hs
		147390 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		433253 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		454797 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		256849 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		442779 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (496-674): 6.85e-19: 95.5: 17.88