HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10373548
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 551
+	Hs
		147382 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		GHR_HUMAN (7-485): 4.72e-75: 252: 16.57
+	Hs
		147385 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96
+	Hs
		147386 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49
+	Mm
		193372 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Hs
		411991 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (5-360): 1.61e-44: 170: 14.48
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (5-360): 1.61e-44: 170: 14.48
+	Hs
		256850 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		IL4RA_HUMAN (1-483): 2.01e-42: 164: 17.49
+	Hs
		412028 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL3RA_HUMAN (10-311): 9.99e-45: 164: 15.36
+	Mm
		435879 HCK_MOUSE (14-223): 4.94e-46: 161: 15.04		CSF3R_MOUSE (7-361): 5.25e-39: 154: 14.80
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (26-243): 6.78e-20: 95.7: 16.14
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (33-243): 2.47e-19: 94.2: 16.74
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (27-351): 1.04e-13: 76.1: 13.11
+	Hs
		412051 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IL3RB_HUMAN (13-240): 2.54e-16: 84.6: 17.01
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (47-288): 1.34e-12: 72.7: 14.17
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (27-351): 1.04e-13: 76.1: 13.11