HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	10707961, 10373548, 16459330
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0009898 - cytoplasmic side of plasma membrane GO:0035556 - intracellular signal transduction GO:0072540 - T-helper 17 cell lineage commitment
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1154
+	Mm
		69807 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		B1ASP2_MOUSE (1-1154): 0: 1021: 94.63
+	Hs
		238424 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Hs
		147366 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Mm
		193387 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Mm
		980968 YES_MOUSE (30-223): 1.41e-50: 173: 15.11		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74
+	Hs
		433222 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGR_HUMAN (868-1151): 8.96e-92: 306: 30.18
+	Hs
		433216 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23
+	Hs
		147406 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		BLK_HUMAN (853-1152): 7.51e-90: 300: 28.15
+	Hs
		147407 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		JAK3_HUMAN (855-1153): 6.11e-32: 137: 18.01
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (578-871): 2.53e-14: 80.1: 27.42
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (566-873): 6e-15: 82: 24.18
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (577-848): 1.87e-14: 80.5: 26.64
+	Hs
		147391 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FGFR3_HUMAN (566-848): 5.13e-13: 75.5: 24.68