HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	12470648
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 894
+	Mm
		763386 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		EPHA4_MOUSE (2-836): 0: 636: 19.66
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (2-837): 0: 605: 19.58
+	Hs
		146667 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		147373 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Mm
		193373 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		INSR_MOUSE (232-851): 2.75e-135: 439: 26.37
+	Hs
		147379 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		433219 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		441406 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Mm
		554964 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		MET_MOUSE (536-799): 5.47e-66: 243: 45.90
+	Hs
		256845 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Mm
		193375 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		FAK1_MOUSE (527-889): 3.59e-57: 215: 34.95
+	Hs
		147414 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		433329 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		111145 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I6L996_HUMAN (527-851): 5.42e-57: 210: 36.83
+	Hs
		111147 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		I6L996_HUMAN (527-851): 5.42e-57: 210: 36.83
+	Mm
		710126 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		FAK1_MOUSE (527-889): 3.59e-57: 215: 34.95
+	Hs
		454825 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		147391 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FGFR3_HUMAN (2-135): 5.06e-15: 81.7: 14.29
+	Hs
		147378 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69