HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	24438103, 12403768, 32548823, 10777583
Identification Methods	enzymatic study, affinity chromatography technology, pull down, unspecified method
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0043066 - negative regulation of apoptotic process GO:0072540 - T-helper 17 cell lineage commitment
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 918
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (1-918): 0: 574: 77.04
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91
+	Hs
		433961 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91
+	Mm
		435879 HCK_MOUSE (14-223): 4.94e-46: 161: 15.04		CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (10-848): 3.46e-89: 304: 20.07
+	Mm
		56907 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PTPRF_MOUSE (32-733): 3.86e-85: 301: 15.40
+	Hs
		411959 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		411565 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		412016 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86
+	Hs
		147385 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83
+	Hs
		434111 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25
+	Hs
		412029 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11
+	Hs
		433804 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		SDK2_HUMAN (242-918): 1.61e-20: 100: 10.01
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (4-824): 4.33e-15: 82.3: 13.77
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (4-824): 4.33e-15: 82.3: 13.77
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (295-801): 5.68e-14: 78.5: 12.94
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (4-824): 4.33e-15: 82.3: 13.77
+	Mm
		817306 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		LEPR_MOUSE (4-824): 4.33e-15: 82.3: 13.77